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References
- Erection Problems
1.Carruthers,
M E. More effective testosterone treatment: Combination
with sildenafil and danazol. Lunenfeld, B. 14(3), 3. 2-10-2000.
New York, London, Parthenon Publishing Group.
Ref Type: Conference Proceeding
Abstract: Testosterone treatment has been used
for over 60 years in the treatment of symptoms of the andropause,
including erectile dysfunction, with varying degrees of success.
The studies reported here were undertaken as part of a retrospective
audit of 1,000 men andropausal men treated for up to 10 years
with testosterone, to establish how the results of treatment
might be improved by the addition of sildenafil (Viagra) or
danazol (Danol).
1,000 patients were treated with testosterone alone, in the
form of testosterone undecanoate (Restandol) or mesterolone
(Pro-Viron), or with testosterone pellet implants (Organon).
Of the 85% of men presenting with erectile dysfunction, and
79% presenting with reduced libido, testosterone improved
the ability to obtain and maintain an erection in 65% and 52%
respectively, and libido increased in 69% of cases, while
also producing significant and sustained relief of all the other
symptoms of the andropause. Of the 100 men treated with sildenafil
in combination with testosterone, erectile function was restored
in 98% and libido in 95%.
The most marked change observed when danazol was added to
the three treatment regimes was in the reduction of Sex Hormone
Binding Globulin, which usually started above the reference
range, and ended at the lower end of it. Those who needed testosterone
implants and Danol to obtain a satisfactory clinical response
were observed to have initially much the highest SHBG levels.
It was concluded that danazol could reduce SHBG to youthful
levels, and thus raise the proportion of free, biologically
active testosterone, greatly enhancing the effectiveness of
testosterone treatment.
Notes:Details the important
synergistic action between testosterone and sildenafil (Viagra),
and the use of danazol (Danol) in increasing the free, biologically
active testosterone level, restoring a more youthful hormonal
pattern. |
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