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| References
- Erection Problems |
| Dinsmore
WW, Hodges M, Hargreaves C, Osterloh IH, Smith MD, Rosen RC.
Sildenafil citrate (Viagra) in erectile dysfunction: near normalization
in men with broad-spectrum erectile dysfunction compared with
age- matched healthy control subjects. Urology 1999;53:800-5.
Abstract: OBJECTIVES: To evaluate the efficacy, safety, and
tolerability of sildenafil in men with broad-spectrum erectile
dysfunction (ED), with reference to age-matched healthy control
subjects. METHODS: One hundred eleven patients were enrolled
in a randomized, double-blind, placebo- controlled, parallel-group,
12-week, flexible-dose study. Efficacy assessments included
the International Index of Erectile Function (IIEF), a global
assessment question, and patient event log data. In a separate,
nontreatment study, 109 control subjects also completed the
IIEF. RESULTS: Mean IIEF scores at baseline were significantly
lower for patients with ED than for control subjects without
a history of ED. After treatment, mean IIEF scores for patients
receiving sildenafil approached values observed in control
subjects and were significantly higher than mean scores for
patients receiving placebo (P<0.01). Responses to the global
assessment question and patient log data corroborated the
IIEF results. Sildenafil was well tolerated, with no discontinuations
because of adverse events. CONCLUSIONS: The results indicate
that sildenafil, an effective oral therapy for the treatment
of broad-spectrum ED, is associated with a near normalization
of patient erectile function
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