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| References
- Heart,
circulation, and the effects of testosterone. |
4.
Jaffe A, Chen Y, Kisch ES, Fischel B, Alon M, Stern
N. Erectile dysfunction in hypertensive subjects. Assessment
of potential determinants. Hypertension 1996;28:859-862.
Abstract: Hypertension is often cited as a risk factor
for erectile dysfunction. To clarify the relation between hypertension
and erectile dysfunction, we evaluated 32 consecutive hypertensive
and 78 normotensive impotent men with respect to multiple potential
determinants and parameters of erectile function, including
medical and sexual history, depression, hormonal profile, penile
nocturnal tumescence, penile vascular supply, and pudendal nerve
conduction. The hypertensive men were older, had higher body
mass index, and used more medications than the normotensive
men. The groups were not different with respect to the prevalence
of smoking and peripheral vascular disease, but the hypertensive
men had a marginally higher rate of ischemic heart disease (P
= .06). The prevalence of depression, abnormal nocturnal penile
tumescence, anomalous pudendal nerve conduction, and impairment
in arterial supply as determined by penile brachial index were
similar in the two groups. Testosterone and bioavailable testosterone
levels were lower in the hypertensive men. After stratification
by age and body mass index, hypertensive men younger than 50
years with body mass index less than 30 kg/m2 had significantly
lower testosterone levels (12.0 +/- 1.7 versus 21.3 +/- 1.4
nmol/L, P < .02) but not bioavailable testosterone levels
(3.9 +/- 0.7 versus 6.4 +/- 0.7 nmol/L, P < .17) than the
corresponding normotensive group. Prolactin, follicle-stimulating
hormone, and luteinizing hormone levels of the two groups were
not significantly different. Contrary to common belief and with
the exception of lower circulating testosterone levels, the
overall analysis showed little difference between hypertensive
and normotensive men with respect to a wide range of classic
determinants of erectile function. Direct study of the local
vascular erectile apparatus appears necessary for further elucidation
of the mechanisms underlying erectile dysfunction in hypertensive
men.
Notes: Testosterone and bioavailable testosterone levels
were lower in the hypertensive men. With the exception of lower
circulating testosterone levels, the overall analysis showed
little difference between hypertensive and normotensive men
with respect to a wide range of classic determinants of erectile
function.
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