|
| References
- Vasectomy |
|
10.
Fisch H, Laor E, BarChama N, Witkin SS, Tolia BM, Reid RE.
Detection of testicular endocrine abnormalities and their
correlation with serum antisperm antibodies in men following
vasectomy. J.Urol 1989;141:1129-32.
Abstract:
We measured the serum gonadotropin response to gonadotropin-releasing
hormone in 25 men who underwent vasectomy 2 to 64 months before
the study. Ten age-matched fertile men were used as controls.
Baseline serum follicle-stimulating hormone, luteinizing hormone
and testosterone levels were not significantly different between
vasectomized men and controls. However, mean serum follicle-stimulating
and luteinizing hormone responses to an intravenous bolus
injection of 100 mcg. gonadotropin-releasing hormone were
significantly greater in the vasectomy group (p equals 0.008
and 0.003, respectively). There was no correlation between
these responses and the interval after vasectomy. Serum antisperm
antibodies were present in 13 vasectomized men (52 per cent)
using enzyme-linked immunosorbent assay and microagglutination
techniques. A significant correlation (p equals 0.003) was
found between the presence of serum antisperm antibodies and
a normal follicle-stimulating hormone response to gonadotropin-
releasing hormone stimulation. Of 13 patients with demonstrable
antisperm antibody titers 9 (69 per cent) had normal follicle-
stimulating hormone responses, compared to only 1 of 12 (8
per cent) without identifiable antisperm antibody titers.
Our data suggest that certain men following vasectomy have
abnormalities in seminiferous tubule and Leydig cell functions
of the testes. These abnormalities are unrelated to the interval
after vasectomy and are not identifiable with routine static
hormonal measurements. In addition, serum antisperm antibodies
are most likely to be present in men who demonstrate normal
seminiferous tubular activity after vasectomy
|
| back
to reference list - Vasectomy |
| back
to reference library menu |
|
