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- Vasectomy |
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12.
Ying W, Hedman M, de la TB, Jensen F, Pedersen PH, Diczfalusy
E. Effect of vasectomy on the steroid profile of human seminal
plasma. Int.J.Androl 1983;6:116-24.
Abstract:
The effect of vasectomy on the steroid profile of seminal
plasma was studied in 19 healthy men at 4-monthly intervals
during a 2-year post- vasectomy period. The steroids analyzed
by radioimmunoassays were: androstenedione (A), testosterone
(T), dihydrotestosterone (DHT), oestradiol (E2) and the sulphoconjugated
forms of pregnenolone (delta 5P-S), dehydroepiandrosterone
(DHEA-S), testosterone (T-S), dihydrotestosterone (DHT-S),
oestrone (E1-S) and oestradiol (E2-S). The quantitatively
most important steroids present in the seminal plasma were
DHEA-S, delta 5P-S and DHT-S. Vasectomy resulted in a significant
but non-progressive reduction in DHT (40%) and T (23%) levels.
The levels of E2, delta 5P-S and DHT-S also exhibited a smaller
reduction following vasectomy. No significant changes were
observed in the levels of the other steroids studied. The
results are interpreted as suggesting that under normal conditions
the bulk of the steroids present in the ejaculate is contributed
by the accessory reproductive organs. In addition, a significant
part of the DHT and T reach the ejaculate together with the
sperm directly from the testis and/or epididymis. It is suggested
that the normal steroid levels in seminal plasma established
in this investigation could serve as reference values in the
hormonal evaluation of male infertility
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