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| References
- Vasectomy |
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19.
Dennis LK, Dawson DV, Resnick MI. Vasectomy and the risk of
prostate cancer: a meta-analysis examining vasectomy status,
age at vasectomy, and time since vasectomy. Prostate Cancer
Prostatic.Dis. 2002;5:193-203.
Abstract:
The aim of this study was to conduct a quantitative review
of prostate cancer studies to pool relative risk (RR) estimates
on the association between prostate cancer and vasectomy,
in an attempt to determine whether there is an association,
and if so, its magnitude. Random-effects models were examined
along with a linear model for time since vasectomy. The pooled
RR estimate was 1.37 (95% CI=1.15-1.62) based on five cohort
studies and 17 case-control studies. The RR estimate varied
by study design with the lowest risk for population-based
case-control studies. No difference was seen in risk by age
at vasectomy. A linear trend based on the 16 studies reporting
time since vasectomy suggested an 10% increase for each additional
10 y or a RR of 1.32 (95% CI=1.17-1.50) for 30 y since vasectomy.
When null effects were assumed for the six studies not reporting
information, the linear RR for the 22 studies was 1.07 (1.03-1.11)
and 1.23 (1.11-1.37) for 10 and 30 y since vasectomy, respectively.
These results suggest that men with a prior vasectomy may
be at an increased risk of prostate cancer, however, the increase
may not be causal since potential bias cannot be discounted.
The overall association was small and therefore could be explained
by bias. The latency effect shown here for time since vasectomy
should be examined further
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