|
| References
- Vasectomy |
|
3.
Bohring C,.Krause W. Differences in the antigen pattern recognized
by antisperm antibodies in patients with infertility and vasectomy.
J.Urol 2001;166:1178-80.
Abstract:
PURPOSE: Antisperm antibodies may impair sperm fertilizing
capacity. They are found in infertile patients and in men
after vasectomy. Little is known to date of the biochemical
nature of the antigens that induce the production of antisperm
antibodies. MATERIALS AND METHODS: Sperm membrane proteins
were prepared from donor spermatozoa, separated by 1- dimensional
polyacrylamide gel electrophoresis and exposed to seminal
plasma samples of 36 infertile men and 34 after vasectomy
containing antisperm antibodies. RESULTS: Ten antigenic protein
bands with different molecular weight were recognized by antisperm
antibodies. Antisperm antibodies binding to the antigen band
at 55 kDa. were significantly more common in infertile men,
while those binding to the 72 kDa. band were more common after
vasectomy. Significant differences also occurred in the incidence
of detecting the 55 kDa. antigen band by the antisperm antibodies
of patients with and without varicocele. Comparing antisperm
antibodies from patients with or without a history of genital
diseases or trauma did not reveal significant differences
in the antigens detected. CONCLUSIONS: It seems likely that
the development of antisperm antibody binding to different
antigens is related to the mode of antibody induction. Since
the antigenic properties of spermatozoa change during passage
through the epididymis, the antigens detected by antisperm
antibodies from men with vasectomy are mostly related to epididymal
passage. The identification of human sperm antigens is essential
for understanding the mechanism by which antisperm antibodies
influence the fertilization capacity of spermatozoa. It is
also necessary for the potential development of reliable diagnostic
methods for antisperm antibodies that are relevant to infertility
|
| back
to reference list - Vasectomy |
| back
to reference library menu |
|
