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| References
- Vasectomy |
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7.
Jarow JP, Goluboff ET, Chang TS, Marshall FF. Relationship
between antisperm antibodies and testicular histologic changes
in humans after vasectomy. Urology 1994;43:521-4.
Abstract:
OBJECTIVE. To determine whether or not there is an association
between testicular histologic changes and antisperm antibodies
in vasectomized men. METHODS. Morphometry was performed on
testicular biopsy specimens obtained from 19 vasectomized
men and 21 fertile control subjects. Antisperm antibody status
was determined on the serum of each patient and control subject
using the indirect immunobead assay. RESULTS. Significant
increases in seminiferous tubule wall thickness (p < 0.001),
focal interstitial fibrosis (p < 0.001), and percent composition
of interstitium (p < 0.01) were observed in vasectomized men
as compared with control subjects. Serum antisperm activity
was present in 74 percent of the vasectomized men but none
in the control subjects (p < 0.001). There was no association
between testicular histologic changes and immune status. CONCLUSIONS.
Vasectomized men exhibit significant testicular histologic
changes and increased autoimmune activity as compared with
fertile control subjects. These histologic changes are not
directly associated with antisperm antibody status, suggesting
that some other pathophysiologic process must be responsible
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